ABSTRACT
Background: Polycystic ovarian syndrome [PCOS] represent one of the common endocrine disorders which influence around 8% of reproductive women whom usually suffering from obesity and increase cardiovascular risk. Serum homocysteine levels are associated with bad impact on endothelial functions and considered as an independent risk factor for cardiovascular disease
Objective:The aim was to study the level of plasma homocysteine in obese and non-obese Iraqi patients with PCOS
Materials and Methods:This study was carried out on 207 women. Of theme, 101 women with PCOS and 106 PCOS- free women served as controls. Blood sample was taken from each participant on the 2[nd] day of menstruation morning after an overnight fasting. Serum levels of follicle-stimulating hormone [FSH], luteinizing hormone [LH], free testosterone and androstenedione were measured. Moreover, total lipid profile and plasma homocysteine levels were measured in both groups
Results: Sixty percent of PCOS women were overweight or obese and 56% of them had a waist circumference >88cm. Moreover plasma homocysteine concentrations were found to be higher in patients with PCOS [11.5 +/- 5.41micro mol/L] as compared with control [8.10 +/- 1.89 micro mol/L] [p<0.002]. Furthermore the homocysteine concentrations were 13.19 +/- 5.97 micro mol/L and 9.38 +/- 2.99 micro mol/L in both obese and normal-weight PCOS women respectively which was significantly higher than obese [p<0.002] and normal-weight [p<0.004] control women
Conclusion:Increase in body weight is not an independent risk factor to increase plasma homocysteine levels in PCOS women